CGGBP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UFW8 |
Other Accession | Q8BHG9, NP_001008391.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 18820 Da |
Antigen Region | 126-152 aa |
Gene ID | 8545 |
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Other Names | CGG triplet repeat-binding protein 1, CGG-binding protein 1, 20 kDa CGG-binding protein, p20-CGGBP DNA-binding protein, CGGBP1, CGGBP |
Target/Specificity | This CGGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-152 amino acids from the C-terminal region of human CGGBP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CGGBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CGGBP1 |
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Synonyms | CGGBP |
Function | Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. |
Cellular Location | Nucleus. |
Tissue Location | Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.
References
Gulyi, P.V., et al. Tsitologiia 51(12):1005-1012(2009)
Arrieta, I., et al. Hum. Biol. 80(6):593-600(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Naumann, F., et al. Genomics 83(1):106-118(2004)
Chen, L.S., et al. Hum. Mol. Genet. 12(23):3067-3074(2003)
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