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CRYGD Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CRYGD Antibody (Center) AP18816c
    CRYGD Antibody (Center)(Cat. #AP18816c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRYGD antibody detected the CRYGD protein (arrow).
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P07320
Other Accession P10067, NP_008822.2
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20738 Da
Antigen Region 73-101 aa
Additional Information
Gene ID 1421
Other Names Gamma-crystallin D, Gamma-D-crystallin, Gamma-crystallin 4, CRYGD, CRYG4
Target/Specificity This CRYGD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the Central region of human CRYGD.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRYGD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRYGD
Synonyms CRYG4
Function Crystallins are the dominant structural components of the vertebrate eye lens.
Research Areas
Citations (0)
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Background

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

References

Acosta-Sampson, L., et al. J. Mol. Biol. 401(1):134-152(2010)
Wang, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(30):13282-13287(2010)
Pande, A., et al. Biochemistry 49(29):6122-6129(2010)
Das, P., et al. Protein Sci. 19(1):131-140(2010)
Roshan, M., et al. Mol. Vis. 16, 887-896 (2010) :

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$ 182.50
$ 70.00
Cat# AP18816c
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