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ADCY5 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95622 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 138908 Da |
| Gene ID | 111 |
|---|---|
| Other Names | Adenylate cyclase type 5, ATP pyrophosphate-lyase 5, Adenylate cyclase type V, Adenylyl cyclase 5, ADCY5 |
| Target/Specificity | This ADCY5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 604-639 amino acids from the Central region of human ADCY5. |
| Dilution | WB~~1:1000-1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADCY5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADCY5 |
|---|---|
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250|UniProtKB:P84309} |
| Tissue Location | Detected in pancreas islets (at protein level). Expressed in the brain, with high expression in the corpus striatum (PubMed:26085604). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ludwig M.G.,et al.J. Recept. Signal Transduct. 22:79-110(2002).
Raimundo S.,et al.Clin. Chim. Acta 285:155-161(1999).
Ding Q.,et al.Mol. Pharmacol. 66:921-928(2004).
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