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Tubulin Beta Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P07437 |
| Reactivity | Human, Mouse, Rat, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50 KDa |
| Antigen Region | 61-160/444 aa |
| Gene ID | 203068 |
|---|---|
| Other Names | Tubulin beta chain, Tubulin beta-5 chain, TUBB, TUBB5 |
| Dilution | IF~~1:100~1:200 WB~~1:100~1:500 IHC-P~~1:100~1:500 IHC~~1:100-1:500 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | TUBB |
|---|---|
| Synonyms | TUBB5 |
| Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | Ubiquitously expressed with highest levels in spleen, thymus and immature brain. |
Provided below are standard protocols that you may find useful for product applications.
Background
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
References
Lee M.G.-S.,et al.Cell 33:477-487(1983).
Hall J.L.,et al.Mol. Cell. Biol. 3:854-862(1983).
Crabtree D.V.,et al.Bioorg. Med. Chem. 9:1967-1976(2001).
Yu W.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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