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ABCD4 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ABCD4 Antibody AP50947
    All lanes : Anti-ABCD4 Antibody at 1:1000 dilution Lane 1: Raji whole cell lysates Lane 2: Jurkat whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 69 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O14678
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 73 KDa
Antigen Region 91 - 150 aa
Additional Information
Gene ID 5826
Other Names ATP-binding cassette sub-family D member 4, PMP70-related protein, P70R, Peroxisomal membrane protein 1-like, PXMP1-L, Peroxisomal membrane protein 69, PMP69, ABCD4, PXMP1L
Target/Specificity KLH conjugated synthetic peptide derived from human ABCD4
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ABCD4 (HGNC:68)
Synonyms PXMP1L
Function Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner (PubMed:22922874, PubMed:33845046, PubMed:28572511, PubMed:31467407). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Targeted by LMBRD1 lysosomal chaperone to the lysosomal membrane.
Tissue Location Ubiquitous.
Citations (0)
citation

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Background

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.

References

Holzinger A.,et al.Biochem. Biophys. Res. Commun. 237:152-157(1997).
Holzinger A.,et al.FEBS Lett. 426:238-242(1998).
Shani N.,et al.Hum. Mol. Genet. 6:1925-1931(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 350.00
Cat# AP50947
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Availability: 2 weeks
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