CD158g Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q14953 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 34 KDa |
Antigen Region | 141 - 200 aa |
Gene ID | 3810 |
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Other Names | Killer cell immunoglobulin-like receptor 2DS5, CD158 antigen-like family member G, MHC class I NK cell receptor, Natural killer-associated transcript 9, NKAT-9, CD158g, KIR2DS5, CD158G, NKAT9 |
Target/Specificity | KLH conjugated synthetic peptide derived from human CD158g |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | KIR2DS5 {ECO:0000303|PubMed:18624290, ECO:0000312|HGNC:HGNC:6337} |
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Function | Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 represented in this entry (PubMed:28685972). |
Cellular Location | Cell membrane; Single-pass type I membrane protein; Extracellular side |
Tissue Location | Expressed on a discrete subset of peripheral blood NK cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
References
Doehring C.,et al.Immunogenetics 44:227-230(1996).
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