PBR Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P30536 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 32 KDa |
Antigen Region | 101 - 160 aa |
Gene ID | 706 |
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Other Names | Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR, TSPO, BZRP, MBR |
Target/Specificity | KLH conjugated synthetic peptide derived from human PBR |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | TSPO |
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Synonyms | BZRP, MBR |
Function | Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral- type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678). |
Cellular Location | Mitochondrion membrane; Multi-pass membrane protein |
Tissue Location | Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity).
References
Riond J.,et al.Eur. J. Biochem. 195:305-311(1991).
Yakovlev A.G.,et al.Gene 155:201-205(1995).
Costa B.,et al.Mol. Pharmacol. 69:37-44(2006).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
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