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COX IV Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • IP - COX IV Antibody AP52659
    Immunoprecipitation analysis of Hela cell lysates using COX IV mouse mAb.
    detail
  • WB - COX IV Antibody AP52659
    Western blot detection of COX IV in Mouse skeletal muscel and Jurkat lysates using COX IV mouse mAb (1:1000 diluted). Predicted band size: 17KDa.Observed band size: 17KDa.
    detail
  • FC - COX IV Antibody AP52659
    Flow Cytometry analysis of K562 cells stained with COX4 (red, 1/100 dilution), followed by FITC-conjugated goat anti-mouse IgG. Blue line histogram represents the isotype control, normal mouse IgG.
    detail
  • ICC - COX IV Antibody AP52659
    Immunocytochemistry of HeLa cells using anti-COX IV mouse mAb diluted 1:150.
    detail
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, ICC, IP
Primary Accession P13073
Reactivity Human, Mouse, Neisseria Gonorrhoeae
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 17 KDa
Additional Information
Gene ID 1327
Other Names AL024441;COX 4;COX IV 1;COX IV;COX IV-1;Cox4;COX41_HUMAN;Cox4a;COX4B;COX4I1;COX4I2; COX4L2;COXIV;Cytochrome c oxidase polypeptide IV;Cytochrome c oxidase subunit 4 isoform 1 mitochondrial;Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;Cytochrome C Oxidase subunit IV;Cytochrome c oxidase subunit IV isoform 1;Cytochrome c oxidase subunit IV isoform 2 (lung);Cytochrome c oxydase subunit;dJ857M17.2;MGC105470;MGC72016.
Dilution IP~~1:500
WB~~1:1000
FC~~1:100
ICC~~1:150
Format Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.09% (W/V) sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name COX4I1 (HGNC:2265)
Function Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Cellular Location Mitochondrion inner membrane; Single-pass membrane protein
Tissue Location Ubiquitous.
Research Areas
Citations ( 0 )

Background

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

References

Zeviani M.,et al.Gene 55:205-217(1987).
Lomax M.I.,et al.Gene 86:209-216(1990).
Park S.J.,et al.Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
Bachman N.J.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.

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$ 370.00
Cat# AP52659
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