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Cyclin H Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | P51946 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Calculated MW | 38 KDa |
| Gene ID | 902 |
|---|---|
| Other Names | 6330408H09Rik;AI661354;AV102684;AW538719;CAK;CAK complex subunit;ccnh;CCNH_HUMAN;CDK activating kinase;CDK activating kinase complex subunit;Cyclin dependent kinase activating kinase;cyclin dependent kinase activating kinase complex subunit;Cyclin H; CyclinH;MO15-associated protein;p34;p36;p37. |
| Dilution | IP~~1:500 WB~~1:1000 |
| Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide, 50% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CCNH |
|---|---|
| Function | Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
References
Maekelae T.P.,et al.Nature 371:254-257(1994).
Fisher R.P.,et al.Cell 78:713-724(1994).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Shiekhattar R.,et al.Nature 374:283-287(1995).
Kershnar E.,et al.J. Biol. Chem. 273:34444-34453(1998).
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