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EIF4EBP3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - EIF4EBP3 Antibody AP52866
    Western blot detection of EIF4EBP3 in CHO-K1 cell lysate(B)and CHO-K1 transfected by EGFP-EIF4EBP3 fragment(A)cell lysate using EIF4EBP3 mouse mAb (1:1000 diluted).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O60516
Reactivity Transfected
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 11 KDa
Additional Information
Gene ID 8637
Other Names 4E BP3; 4E-BP3; 4EBP3; eIF4E binding protein 3; Eukaryotic initiation factor 4E binding protein 3; Eukaryotic translation initiation factor 4E binding protein 3; OTTHUMP00000159879.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name EIF4EBP3
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010).
Cellular Location Cytoplasm. Nucleus
Tissue Location Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.
Citations (0)
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Background

Regulates eIF4E activity by preventing its assembly into the eIF4F complex.

References

Poulin F.,et al.J. Biol. Chem. 273:14002-14007(1998).

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$ 360.00
Cat# AP52866
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