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KMT3C / SMYD2 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NRG4 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Calculated MW | 50 KDa |
| Gene ID | 56950 |
|---|---|
| Other Names | Histone methyltransferase SMYD2;HSKM B;HSKM-B;HSKMB;KMT3C;Lysine N-methyltransferase 3C; MGC119305;N lysine methyltransferase SMYD2;N-lysine methyltransferase SMYD2;SET and MYND domain containing 2;SET and MYND domain containing protein 2;SET and MYND domain-containing protein 2;Smyd2;SMYD2_HUMAN;Zinc finger MYND domain containing 14;ZMYND14. |
| Dilution | WB~~1:1000 |
| Format | ascites |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SMYD2 |
|---|---|
| Synonyms | KMT3C |
| Function | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
References
Li Y.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Huang J.,et al.Nature 444:629-632(2006).
Wang C.,et al.Cell Res. 17:374-383(2007).
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