Claudin 2 (CLDN2) Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | P57739 |
Other Accession | O88552, Q765P1, NP_065117 |
Reactivity | Human |
Predicted | Bovine, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 24549 Da |
Antigen Region | 135-164 aa |
Gene ID | 9075 |
---|---|
Other Names | Claudin-2, SP82, CLDN2 |
Target/Specificity | This Claudin 2 (CLDN2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the N-terminal region of human Claudin 2 (CLDN2). |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Claudin 2 (CLDN2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLDN2 |
---|---|
Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:O88552}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O88552} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions.
References
Morita,K., Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)
Furuse,M., J. Cell Biol. 141 (7), 1539-1550 (1998)
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