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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DCN Antibody (Center)   

DCN Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DCN Antibody (Center) AP6590c
    Western blot analysis of DCN antibody (Center) (Cat. #AP6590c) in mouse heart tissue lysates (35ug/lane). DCN (arrow) was detected using the purified Pab.
    detail
  • WB - DCN Antibody (Center) AP6590c
    Western blot analysis of DCN (arrow) using rabbit polyclonal DCN Antibody (Center) (Cat. #AP6590c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DCN gene.
    detail
  • IHC-P - DCN Antibody (Center) AP6590c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with DCN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - DCN Antibody (Center) AP6590c
    DCN Antibody (Center) (Cat.#AP6590c) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, FC, WB, E
Primary Accession P07585
Other Accession Q9XSD9, P21793, Q9TTE2
Reactivity Human, Mouse
Predicted Bovine, Pig, Sheep
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 39747 Da
Antigen Region 122-150 aa
Additional Information
Gene ID 1634
Other Names Decorin, Bone proteoglycan II, PG-S2, PG40, DCN, SLRR1B
Target/Specificity This DCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the Central region of human DCN.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDCN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCN
Synonyms SLRR1B
Function May affect the rate of fibrils formation.
Cellular Location Secreted, extracellular space, extracellular matrix. Secreted
Tissue Location Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid, fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717).
Research Areas
Citations ( 0 )

Background

DCN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines.

References

Goldoni,S., J. Cell Biol. 185 (4), 743-754 (2009)

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$ 365.00
$ 140.00
Cat# AP6590c
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