DCN Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, FC, WB, E |
---|---|
Primary Accession | P07585 |
Other Accession | Q9XSD9, P21793, Q9TTE2 |
Reactivity | Human, Mouse |
Predicted | Bovine, Pig, Sheep |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39747 Da |
Antigen Region | 122-150 aa |
Gene ID | 1634 |
---|---|
Other Names | Decorin, Bone proteoglycan II, PG-S2, PG40, DCN, SLRR1B |
Target/Specificity | This DCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the Central region of human DCN. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DCN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DCN |
---|---|
Synonyms | SLRR1B |
Function | May affect the rate of fibrils formation. |
Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted |
Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid, fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). |
Provided below are standard protocols that you may find useful for product applications.
Background
DCN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines.
References
Goldoni,S., J. Cell Biol. 185 (4), 743-754 (2009)
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