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WNT1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - WNT1 Antibody (C-term) AP6785B
    Western blot analysis of WNT1 Antibody (C-term) (Cat. #AP6785b) in mouse heart tissue lysates (35ug/lane). WNT1 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - WNT1 Antibody (C-term) AP6785B
    WNT1 Antibody (C-term) (Cat. #AP6785b) IHC analysis in formalin fixed and paraffin embedded human testis followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the WNT1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • FC - WNT1 Antibody (C-term) AP6785B
    WNT1 Antibody (C-term) (Cat. #AP6785b) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession P04628
Other Accession P04426
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 40982 Da
Antigen Region 260-288 aa
Additional Information
Gene ID 7471
Other Names Proto-oncogene Wnt-1, Proto-oncogene Int-1 homolog, WNT1, INT1
Target/Specificity This WNT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the C-terminal region of human WNT1.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWNT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WNT1
Synonyms INT1
Function Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).
Cellular Location Secreted, extracellular space, extracellular matrix. Secreted
Research Areas
Citations ( 0 )

Background

WNT1 is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum.

References

Shuai,X., et.al., Cancer Genet. Cytogenet. 194 (2), 119-124 (2009)

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$ 182.50
$ 70.00
Cat# AP6785B
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