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FASTK Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FASTK Antibody (C-term) AP7084b
    Western blot analysis of hFASTK-R534 (Cat. #AP7084b) in Jurkat cell line lysates (35ug/lane).FASTK (arrow) was detected using the purified Pab.
    detail
  • WB - FASTK Antibody (C-term) AP7084b
    Western blot analysis of hFASTK-R534 (Cat. #AP7084b) in mouse heart tissue lysates (35ug/lane).FASTK (arrow) was detected using the purified Pab.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14296
Other Accession NP_006703
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 61104 Da
Antigen Region 519-549 aa
Additional Information
Gene ID 10922
Other Names Fas-activated serine/threonine kinase, FAST kinase, FASTK
Target/Specificity This FASTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 519-549 amino acids from the C-terminal region of human FASTK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFASTK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FASTK
Function Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro- apoptotic form of the receptor.
Cellular Location [Isoform 4]: Mitochondrion matrix. Note=Colocalizes with mitochondrial RNA granules.
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, anbapoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis.

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$ 182.50
$ 70.00
Cat# AP7084b
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