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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PDXK Antibody (C-term)   

PDXK Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDXK Antibody (C-term) AP7167a
    Western blot analysis of anti-PDXK (Cat. #AP7167a) in HepG2 cell line lysate (35ug/lane).PDXK(arrow) was detected using the purified Pab.
  • IHC-P - PDXK Antibody (C-term) AP7167a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00764
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35102 Da
Antigen Region 242-272 aa
Additional Information
Gene ID 8566
Other Names Pyridoxal kinase, Pyridoxine kinase, PDXK, C21orf124, C21orf97, PKH, PNK
Target/Specificity This PDXK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-272 amino acids from the C-terminal region of human PDXK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDXK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C21orf124, C21orf97, PKH, PNK
Function Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous. Isoform 3 is detected in adult testis and spermatozoa
Research Areas
Citations (0)

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Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.


Shin, J.H., et al., Neurochem. Int. 45(1):73-79 (2004).
Lee, H.S., et al., Mol. Cells 10(4):452-459 (2000).
Laine-Cessac, P., et al., Biochem. Pharmacol. 54(8):863-870 (1997).
Hanna, M.C., et al., J. Biol. Chem. 272(16):10756-10760 (1997).
Zhang, Z., et al., J. Nutr. 10(1):53-59 (1993).

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Cat# AP7167a
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