DPT Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IF, FC, IHC-P, WB, E |
---|---|
Primary Accession | Q07507 |
Other Accession | P45846, Q9QZZ6, P19427 |
Reactivity | Human |
Predicted | Bovine, Mouse, Pig |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 24005 Da |
Antigen Region | 102-128 aa |
Gene ID | 1805 |
---|---|
Other Names | Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT |
Target/Specificity | This DPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-128 amino acids from the Central region of human DPT. |
Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DPT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DPT |
---|---|
Function | Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DPT is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. This protein is found in various tissues and many of its tyrosine residues are sulphated. The protein is postulated to modify the behavior of TGF-beta through interaction with decorin.
References
Cheung,C.L., Chan,B.Y. Hum. Mol. Genet. 18 (4), 679-687 (2009)
Pochampally,R.R., Ylostalo,J. J. Bone Miner. Res. 22 (9), 1338-1349 (2007)
Lunetta,K.L., D'Agostino,R.B. Sr. BMC Med. Genet. 8 SUPPL 1, S13 (2007)
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