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BDNF Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IF, IHC-P, E |
|---|---|
| Primary Accession | P23560 |
| Other Accession | P23363, P14082, P21237, Q95106, Q0EAB7 |
| Reactivity | Human |
| Predicted | Bovine, Horse, Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27818 Da |
| Antigen Region | 206-236 aa |
| Gene ID | 627 |
|---|---|
| Other Names | Brain-derived neurotrophic factor, BDNF, Abrineurin, BDNF |
| Target/Specificity | This BDNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the C-terminal region of human BDNF. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BDNF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BDNF {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:1033} |
|---|---|
| Function | Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this protein is reduced in both Alzheimer's and Huntington disease patients. This protein may play a role in the regulation of stress response and in the biology of mood disorders.
References
Jiang,H., Clin. Chim. Acta 400 (1-2), 3-7 (2009)
Liu,L., Psychiatr. Genet. 18 (6), 267-274 (2008)
Dmitrzak-Weglarz,M., Pharmacogenomics 9 (11), 1595-1603 (2008)
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$ 365.00
$ 140.00
Cat# AP7979B
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