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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > LTC4S Antibody (N-term)
LTC4S Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16873 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16567 Da |
| Antigen Region | 29-55 aa |
| Gene ID | 4056 |
|---|---|
| Other Names | Leukotriene C4 synthase, LTC4 synthase, Leukotriene-C(4) synthase, LTC4S |
| Target/Specificity | This LTC4S antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-55 amino acids from the N-terminal region of human LTC4S. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LTC4S Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LTC4S |
|---|---|
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:7937884, PubMed:27791009, PubMed:27365393, PubMed:9153254, PubMed:23409838). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). |
| Cellular Location | Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein |
| Tissue Location | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
LTC4S catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
References
Song,X.Y., et.al., Diabetologia 52 (8), 1543-1553 (2009)
Schurks,M., et.al., J Pain 10 (7), 759-766 (2009)
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$ 365.00
$ 140.00
Cat# AP8584a
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