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TRIB2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q92519 |
| Other Accession | Q8K4K3, Q5GLH2, NP_067675 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38801 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 28951 |
|---|---|
| Other Names | Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809) |
| Target/Specificity | This TRIB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIB2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIB2 (HGNC:30809) |
|---|---|
| Function | Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton. |
| Tissue Location | Highly expressed in peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
References
Hegele,R.A., et.al., Hum. Mol. Genet. 18 (21), 4189-4194 (2009)
Eder,K., et.al., Int. Immunol. 20 (12), 1543-1550 (2008)
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