CREM Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
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Primary Accession | Q03060 |
Other Accession | Q03061, P27699, Q1LZH5 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37006 Da |
Antigen Region | 287-314 aa |
Gene ID | 1390 |
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Other Names | cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM |
Target/Specificity | This CREM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human CREM. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CREM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CREM (HGNC:2352) |
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Function | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). |
Cellular Location | Nucleus. |
Tissue Location | Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes |
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Provided below are standard protocols that you may find useful for product applications.
Background
CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes.
References
Fujimoto,T., et.al., J. Biochem. 115 (2), 298-303 (1994)
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