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SELT Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SELT Antibody (N-term) AP9306a
    Western blot analysis of SELT Antibody (N-term) (Cat. #AP9306a) in MCF-7 cell line lysates (35ug/lane). SELT (arrow) was detected using the purified Pab.
    detail
  • FC - SELT Antibody (N-term) AP9306a
    SELT Antibody (N-term) (Cat. #AP9306a) flow cytometry analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession P62341
Other Accession Q1H5H1, P62342, Q5ZJN8, A6QP01
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 22324 Da
Antigen Region 48-75 aa
Additional Information
Gene ID 51714
Other Names Selenoprotein T, SelT, SELT
Target/Specificity This SELT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human SELT.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSELT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SELENOT {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:18136}
Function Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (By similarity).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein
Tissue Location Ubiquitous. Highly expressed in the endocrine pancreas.
Research Areas
Citations (0)
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Background

SELT encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

References

Kryukov,G.V., et.al., Science 300 (5624), 1439-1443 (2003)
Kryukov,G.V., et.al., J. Biol. Chem. 274 (48), 33888-33897 (1999)

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$ 365.00
$ 140.00
Cat# AP9306a
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