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TSPAN33 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q86UF1 |
| Other Accession | Q8R3S2, Q3SYV5 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31538 Da |
| Antigen Region | 254-283 aa |
| Gene ID | 340348 |
|---|---|
| Other Names | Tetraspanin-33, Tspan-33, Penumbra, hPen, Proerythroblast new membrane, TSPAN33, PEN |
| Target/Specificity | This TSPAN33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-283 amino acids from the C-terminal region of human TSPAN33. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSPAN33 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSPAN33 (HGNC:28743) |
|---|---|
| Synonyms | PEN |
| Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:30463011, PubMed:37516108). Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11- dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Cytoplasm. Note=Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction |
| Tissue Location | Predominantly expressed in erythroblasts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TSPAN33 plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors.
References
Heikens, M.J., et al. Blood 109(8):3244-3252(2007)
Huang, S., et al. Genomics 86(6):674-684(2005)
Chen, Z., et al. Cancer Genet. Cytogenet. 162(2):95-98(2005)
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