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ABHDB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8NFV4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33747 Da |
| Antigen Region | 176-205 aa |
| Gene ID | 83451 |
|---|---|
| Other Names | Alpha/beta hydrolase domain-containing protein 11, Abhydrolase domain-containing protein 11, 3---, Williams-Beuren syndrome chromosomal region 21 protein, ABHD11, WBSCR21 |
| Target/Specificity | This ABHDB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-205 amino acids from the Central region of human ABHDB. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ABHDB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABHD11 (HGNC:16407) |
|---|---|
| Synonyms | WBSCR21 |
| Function | Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (PubMed:32579589). 1,2- diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn- glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (PubMed:32792488). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity). |
| Cellular Location | Mitochondrion. Mitochondrion matrix |
| Tissue Location | Ubiquitously expressed (PubMed:12073013). Highly expressed in small intestine, prostate and thyroid, while aorta and colon tissues exhibit weak expression levels (PubMed:32579589) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ABHDB encodes a protein containing an alpha/beta hydrolase fold domain. This protein is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.
References
Tsuritani, K., et al. Genome Res. 17(7):1005-1014(2007)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Merla, G., et al. Hum. Genet. 110(5):429-438(2002)
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