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TMEM108 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6UXF1 |
| Other Accession | Q8BHE4, A6QLF8 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59948 Da |
| Antigen Region | 524-553 aa |
| Gene ID | 66000 |
|---|---|
| Other Names | Transmembrane protein 108, TMEM108, KIAA1690 |
| Target/Specificity | This TMEM108 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 524-553 amino acids from the C-terminal region of human TMEM108. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMEM108 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM108 (HGNC:28451) |
|---|---|
| Synonyms | KIAA1690, RTLN |
| Function | Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q8BHE4}; Multi- pass membrane protein. Postsynaptic density {ECO:0000250|UniProtKB:Q8BHE4}. Endosome membrane {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHE4}. Early endosome {ECO:0000250|UniProtKB:Q8BHE4} |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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$ 365.00
$ 140.00
Cat# AP9598b
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