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BCL11A Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BCL11A Antibody (C-term) AP9630b
    Western blot analysis of BCL11A Antibody (C-term) (Cat. #AP9630b) in Jurkat, Ramos, 293, NCI-H460 cell line lysates (35ug/lane). BCL11A (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H165
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 91197 Da
Antigen Region 806-835 aa
Additional Information
Gene ID 53335
Other Names B-cell lymphoma/leukemia 11A, BCL-11A, B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, EVI-9, Zinc finger protein 856, BCL11A, CTIP1, EVI9, KIAA1809, ZNF856
Target/Specificity This BCL11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 806-835 amino acids from the C-terminal region of human BCL11A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCL11A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL11A
Synonyms CTIP1, EVI9, KIAA1809, ZNF856
Function Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).
Cellular Location Cytoplasm. Nucleus. Chromosome. Note=Associates with the nuclear body Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity) [Isoform 2]: Cytoplasm. Nucleus Note=Predominantly localized in the nucleus in nuclear paraspeckles
Tissue Location Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.
Research Areas
Citations (0)
citation

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Background

BCL11A is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6.

References

Solovieff, N., et al. Blood 115(9):1815-1822(2010)
Nuinoon, M., et al. Hum. Genet. 127(3):303-314(2010)

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$ 365.00
$ 140.00
Cat# AP9630b
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