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COMMD7 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q86VX2 |
| Other Accession | NP_444269, 151101369 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 22 kDa Observed: 21 kDa |
| Application Notes | COMMD7 antibody can be used for detection of COMMD7 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 149951 |
|---|---|
| Target/Specificity | COMMD7; COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7. |
| Reconstitution & Storage | COMMD7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | COMMD7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COMMD7 |
|---|---|
| Synonyms | C20orf92 |
| Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966). |
| Cellular Location | Cytoplasmic vesicle |
| Tissue Location | Widely expressed with highest expression in lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1). It associates with the NF-kB complex and suppresses its transcriptional activity (2). COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3). COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4). COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4).
References
Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6.
Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32.
Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry 2007; 46:3116-28.
Zheng L, Liang P, Li J, et al. ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth. PLoS One 2012; 7:e45412.
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