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BAMBI Antibody

     
  • WB - BAMBI Antibody ASC11837
    Western blot analysis of BAMBI in mouse lung tissue lysate with BAMBI antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
    detail
  • IHC - BAMBI Antibody ASC11837
    Immunohistochemistry of BAMBI in human lung tissue with BAMBI antibody at 5 µg/ml.
    detail
  • IF - BAMBI Antibody ASC11837
    Immunofluorescence of BAMBI in human lung tissue with BAMBI antibody at 20 µg/ml.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q13145
Other Accession NP_036474, 6912534
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 29 kDa

Observed: 26 kDa
Application Notes BAMBI antibody can be used for detection of BAMBI by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 25805
Target/Specificity BAMBI; BAMBI antibody is human, mouse and rat reactive.
Reconstitution & Storage BAMBI antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsBAMBI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAMBI
Synonyms NMA
Function Negatively regulates TGF-beta signaling.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested
Research Areas
Citations (0)
citation

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Background

BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development (1). BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4 (2,3). BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues (4). BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines (5).

References

Onichtchouk D, Chen YG, Dosch R, et al. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999; 401:480-5.
Yan X, Lin Z, Chen F, et al. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol. Chem. 2009; 284:30097-104.
Grotewold L, Plum M, Dildrop R, et al. Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech. Dev. 2001; 100:327-30.
Fritzmann J, Morkel M, Besser D, et al. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 2009; 137:165-75.

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$ 379.00
Cat# ASC11837
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