TrpV3 Antibody
TRPV3 Antibody, Clone S15-39
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC/IF, IP, AM |
---|---|
Primary Accession | Q4QYD9 |
Other Accession | NP_001020928 |
Host | Mouse |
Isotype | IgG2a |
Reactivity | Human, Mouse, Rat |
Clonality | Monoclonal |
Description | Mouse Anti-Rat TrpV3 Monoclonal IgG2a |
Target/Specificity | Detects ~70kDa. |
Other Names | VRL3 Antibody, vanilloid receptor 2 Antibody, transient receptor potential cation channel subfamily V member 3 Antibody, sensitive channel TRPV3 Antibody, 1110036I10Rik Antibody, MGC124324 Antibody, MGC124325 Antibody, Trpv3 heat sensitive channel Antibody, vanilloid receptor-related osmotically activated channel protein Antibody |
Clone Names | S15-39 |
Immunogen | Synthetic peptide amino acids 458-474 (cytoplasmic C-terminus) of rat TrpV3 |
Purification | Protein G Purified |
Storage | -20ºC |
Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | 1 µg/ml of SMC-334 was sufficient for detection of TrpV3 in 10 µg of COS-1 cell lysate transiently transfected with TrpV3 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody |
Cellular Localization | Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
The TRPV3 protein belongs to a family of non-selective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermo sensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels (1, 2).
References
1. Masamoto Y., Kawabata F., Fushiki T. (2009) Biosci. Biotechnol. Biochem. 73(5): 1021-1027.
2. Xiao R., et al. (2008) J Biol Chem. 283(10): 6162-6174.
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