ABCC6 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ABCC6.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O95255 |
Other Accession | NM_001171 |
Reactivity | Human |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG2b Kappa |
Clone Names | 1E7 |
Calculated MW | 164906 Da |
Gene ID | 368 |
---|---|
Other Names | Multidrug resistance-associated protein 6, ATP-binding cassette sub-family C member 6, Anthracycline resistance-associated protein, Multi-specific organic anion transporter E, MOAT-E, ABCC6, ARA, MRP6 |
Target/Specificity | ABCC6 (NP_001162, 831 a.a. ~ 930 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | ABCC6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
References
Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticum. Zarbock R, et al. Clin Chim Acta, 2010 Oct 9. PMID 20541540.The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. de Boussac H, et al. J Biol Chem, 2010 Jul 23. PMID 20463007.Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. Costrop LM, et al. J Hum Genet, 2010 Feb. PMID 20075945.Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms. Uitto J, et al. J Invest Dermatol, 2010 Mar. PMID 20032990.The R1141X loss-of-function mutation of the ABCC6 gene is a strong genetic risk factor for coronary artery disease. K?bl?s G, et al. Genet Test Mol Biomarkers, 2010 Feb. PMID 19929409.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.