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ESR2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - ESR2 Antibody (Center) AW5289-U100
    Western blot analysis of lysates from human ovary,human testis tissue lysate (from left to right), using ESR2Antibody(Center)(Cat. #AW5289). AW5289 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
    detail
  • FC - ESR2 Antibody (Center) AW5289-U100
    Flow cytometric analysis of HepG2 cells using ESR2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB
Primary Accession Q92731
Other Accession Q62986, Q9XSW2, Q9PTU5, Q9XSB5, Q9TU15
Reactivity Human
Predicted Bovine, Chicken, Pig, Rat, Sheep
Host Rabbit
Clonality Polyclonal
Calculated MW H=59,55,36,58,54,53, KDa
Isotype Rabbit IgG
Antigen Source HUMAN
Additional Information
Gene ID 2100
Antigen Region 369-397 aa
Other Names ESR2; ESTRB; NR3A2; Estrogen receptor beta; Nuclear receptor subfamily 3 group A member 2
Dilution WB~~1:1000
FC~~1:10~50
Target/Specificity This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the Central region of human ESR2.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsESR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESR2
Synonyms ESTRB, NR3A2
Function Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen- dependent manner (PubMed:20074560).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:19126643, ECO:0000269|PubMed:20074560}
Tissue Location [Isoform 1]: Expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. [Isoform 4]: Expressed in the testis. [Isoform 6]: Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Citations (0)
citation

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Background

ESR2 is a nuclear hormone receptor. The protein binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.

References

Chen H., Lin R.J.Cell 90:569-580(1997)
Caira F., Antonson P.J. Biol. Chem. 275:5308-5317(2000)
Bu H., Kashireddy P.Biochem. Biophys. Res. Commun. 317:54-59(2004)

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$ 370.00
Cat# AW5289-U100
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