|Other Names||Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells|
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Provided below are standard protocols that you may find useful for product applications.
The jagged 1 protein encoded by JAG1 is the human homologof the Drosophilia jagged protein. Human jagged 1 is the ligandfor the receptor notch 1, the latter a human homolog of theDrosophilia jagged receptor notch. Mutations that alter the jagged1 protein cause Alagille syndrome. Jagged 1 signalling throughnotch 1 has also been shown to play a role in hematopoiesis.
Foldi, J., et al. J. Immunol. 185(9):5023-5031(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kerns, D., et al. Schizophr. Res. 120 (1-3), 150-158 (2010) :Siar, C.H., et al. Eur. J. Med. Res. 15(4):180-184(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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