|Other Names||Protein Wnt-10a, WNT10A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. It isstrongly expressed in the cell lines of promyelocytic leukemia andBurkitt's lymphoma. In addition, it and another family member, theWNT6 gene, are strongly coexpressed in colorectal cancer celllines. The gene overexpression may play key roles in carcinogenesisthrough activation of the WNT-beta-catenin-TCF signaling pathway.This gene and the WNT6 gene are clustered in the chromosome 2q35region.
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :Memarian, A., et al. Leuk. Lymphoma 50(12):2061-2070(2009)Nawaz, S., et al. Eur. J. Hum. Genet. 17(12):1600-1605(2009)Medland, S.E., et al. Am. J. Hum. Genet. 85(5):750-755(2009)Bohring, A., et al. Am. J. Hum. Genet. 85(1):97-105(2009)
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