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PCDHB3 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y5E6
Clone Names 101008108
Additional Information
Gene ID 56132
Other Names Protocadherin beta-3, PCDH-beta-3, PCDHB3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCDHB3
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)
citation

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Background

This gene is a member of the protocadherin beta genecluster, one of three related gene clusters tandemly linked onchromosome five. The gene clusters demonstrate an unusual genomicorganization similar to that of B-cell and T-cell receptor geneclusters. The beta cluster contains 16 genes and 3 pseudogenes,each encoding 6 extracellular cadherin domains and a cytoplasmictail that deviates from others in the cadherin superfamily. Theextracellular domains interact in a homophilic manner to specifydifferential cell-cell connections. Unlike the alpha and gammaclusters, the transcripts from these genes are made up of only onelarge exon, not sharing common 3' exons as expected. These neuralcadherin-like cell adhesion proteins are integral plasma membraneproteins. Their specific functions are unknown but they most likelyplay a critical role in the establishment and function of specificcell-cell neural connections.

References

Frank, M., et al. Curr. Opin. Cell Biol. 14(5):557-562(2002)Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :Wu, Q., et al. Genome Res. 11(3):389-404(2001)Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)

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$ 277.78
Cat# BP12159a
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Availability: 2 weeks
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