|Other Names||5-hydroxytryptamine receptor 3A, 5-HT3-A, 5-HT3A, 5-hydroxytryptamine receptor 3, 5-HT-3, 5-HT3R, Serotonin receptor 3A, Serotonin-gated ion channel receptor, HTR3A, 5HT3R, HTR3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the ligand-gated ionchannel receptor superfamily. This gene encodes subunit A of thetype 3 receptor for 5-hydroxytryptamine (serotonin), a biogenichormone that functions as a neurotransmitter, a hormone, and amitogen. This receptor causes fast, depolarizing responses inneurons after activation. It appears that the heteromericcombination of A and B subunits is necessary to provide the fullfunctional features of this receptor, since either subunit aloneresults in receptors with very low conductance and responseamplitude. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
Gatt, J.M., et al. Biol. Psychiatry 68(9):818-824(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gatt, J.M., et al. Depress Anxiety 27(8):752-759(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Hammer, C., et al. Pharmacogenomics 11(7):943-950(2010)
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