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PLD1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13393 |
|---|---|
| Clone Names | 71211150 |
| Gene ID | 5337 |
|---|---|
| Other Names | Phospholipase D1, PLD 1, hPLD1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, PLD1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLD1 (HGNC:9067) |
|---|---|
| Function | Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313, PubMed:25936805). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Z280}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Late endosome membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280} |
| Tissue Location | Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphatidylcholine (PC)-specific phospholipases D (PLDs;EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidicacid and choline. A range of agonists acting through Gprotein-coupled receptors and receptor tyrosine kinases stimulatethis hydrolysis. PC-specific PLD activity has been implicated innumerous cellular pathways, including signal transduction, membranetrafficking, and the regulation of mitosis (Hammond et al., 1995[PubMed 8530346]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kang, D.W., et al. Cancer Res. 70(10):4233-4242(2010)Yin, H., et al. J. Biol. Chem. 285(18):13580-13588(2010)Kang, D.W., et al. PLoS ONE 5 (8), E12109 (2010) :
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