|Other Names||Integrator complex subunit 1, Int1, INTS1, KIAA1440|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).|
|Cellular Location||Nucleus membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
INTS1 is a subunit of the Integrator complex, whichassociates with the C-terminal domain of RNA polymerase II largesubunit (POLR2A; MIM 180660) and mediates 3-prime end processing ofsmall nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690)(Baillat et al., 2005 [PubMed 16239144]).
Nusbaum, C., et al. Nature 439(7074):331-335(2006)Baillat, D., et al. Cell 123(2):265-276(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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