|Other Names||Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).|
|Tissue Location||Osteoblast and brain.|
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Provided below are standard protocols that you may find useful for product applications.
PTN ia a heparin binding mitogenic protein. It has neurite extension activity.
Li, F., et al. J. Biol. Chem. 285(36):27673-27685(2010)Dos Santos, C., et al. Int. J. Cancer 127(5):1038-1051(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Svensson, S.L., et al. J. Biol. Chem. 285(21):16105-16115(2010)M'Bika, J.P., et al. J. Gen. Virol. 91 (PT 5), 1346-1353 (2010) :
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