|Other Names||Transducin-like enhancer protein 2, Enhancer of split groucho-like protein 2, ESG2, TLE2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).|
|Tissue Location||In all tissues examined, mostly in heart, brain, and muscle|
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TLE2 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
He, Z., et al. J. Virol. 84(4):2047-2062(2010)Arce, L., et al. BMC Cancer 9, 159 (2009) :Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)Javed, A., et al. J. Cell. Sci. 113 (PT 12), 2221-2231 (2000) :Grbavec, D., et al. Biochem. J. 337 (PT 1), 13-17 (1999) :
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