AQP5 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P55064 |
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Clone Names | 100318042 |
Gene ID | 362 |
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Other Names | Aquaporin-5, AQP-5, AQP5 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AQP5 |
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Function | Forms a water-specific channel (PubMed:8621489, PubMed:18768791). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). |
Cellular Location | Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Note=Hypotonicity increases location at the cell membrane Phosphorylation decreases location at the cell membrane |
Tissue Location | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aquaporin 5 (AQP5) is a water channel protein. Aquaporinsare a family of small integral membrane proteins related to themajor intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role inthe generation of saliva, tears and pulmonary secretions. AQP0,AQP2, AQP5, and AQP6 are closely related and all map to 12q13.
References
Shen, Y., et al. Respir Physiol Neurobiol 171(3):212-217(2010)Shen, L., et al. Biomed. Pharmacother. 64(5):313-318(2010)Shankardas, J., et al. Mol. Vis. 16, 1538-1548 (2010) :Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) :Nejsum, L.N., et al. Proc. Natl. Acad. Sci. U.S.A. 99(1):511-516(2002)
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