Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SLC12A1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13621 |
|---|---|
| Clone Names | 101008194 |
| Gene ID | 6557 |
|---|---|
| Other Names | Solute carrier family 12 member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, SLC12A1, NKCC2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC12A1 |
|---|---|
| Synonyms | NKCC2 {ECO:0000303|PubMed:8640224} |
| Function | Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Kidney; localizes to the thick ascending limbs (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a kidney-specificsodium-potassium-chloride cotransporter that is expressed on theluminal membrane of renal epithelial cells of the thick ascendinglimb of Henle's loop and the macula densa. It plays a key role inconcentrating urine and accounts for most of the NaCl resorption.It is sensitive to such diuretics as furosemide and bumetanide.Some Bartter-like syndromes result from defects in this gene.Alternative splicing results in multiple transcript variantsencoding distinct isoforms. Additional splice variants have beendescribed but their biological validity in humans has not beenexperimentally proven.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Carota, I., et al. Acta Physiol (Oxf) 199(3):327-338(2010)Bralten, L.B., et al. Genes Chromosomes Cancer 49(6):509-517(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Castrop, H., et al. Am. J. Physiol. Renal Physiol. 295 (4), F859-F866 (2008) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
