|Other Names||Insulin receptor substrate 4, IRS-4, 160 kDa phosphotyrosine protein, py160, Phosphoprotein of 160 kDa, pp160, IRS4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma.|
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Provided below are standard protocols that you may find useful for product applications.
IRS4 encodes the insulin receptor substrate 4, acytoplasmic protein that contains many potential tyrosine andserine/threonine phosphorylation sites. Tyrosine-phosphorylatedIRS4 protein has been shown to associate with cytoplasmicsignalling molecules that contain SH2 domains. The IRS4 protein isphosphorylated by the insulin receptor tyrosine kinase uponreceptor stimulation..
Dong, X., et al. Gastroenterology 139(2):464-473(2010)Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Shimwell, N.J., et al. Oncogene 28(5):686-697(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
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