|Other Names||Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1, COX6B1, COX6B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Connects the two COX monomers into the physiological dimeric form.|
|Cellular Location||Mitochondrion intermembrane space|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome c oxidase (COX), the terminal enzyme of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. It is a heteromeric complexconsisting of 3 catalytic subunits encoded by mitochondrial genesand multiple structural subunits encoded by nuclear genes. Themitochondrially-encoded subunits function in electron transfer, andthe nuclear-encoded subunits may be involved in the regulation andassembly of the complex. This nuclear gene encodes subunit VIb.Mutations in this gene are associated with severe infantileencephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 andCOX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2,respectively.
Lazarou, M., et al. FEBS J. 276(22):6701-6713(2009)Massa, V., et al. Am. J. Hum. Genet. 82(6):1281-1289(2008)Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007)Schmidt, T.R., et al. Gene 286(1):13-19(2002)Taanman, J.W., et al. Hum. Genet. 87(3):325-327(1991)
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