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ARPC5 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O15511
Clone Names 101008294
Peptide ID 101008294
Additional Information
Gene ID 10092
Other Names Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC, ARPC5, ARC16
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARPC5
Synonyms ARC16
Function Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation- promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double- strand breaks (DSBs) (PubMed:29925947).
Cellular Location Cytoplasm, cytoskeleton. Cell projection. Nucleus
Research Areas
Citations (0)

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Background

This gene encodes one of seven subunits of the humanArp2/3 protein complex. The Arp2/3 protein complex has beenimplicated in the control of actin polymerization in cells and hasbeen conserved through evolution. The exact role of the proteinencoded by this gene, the p16 subunit, has yet to be determined.

References

Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Singh, S., et al. J. Biol. Chem. 278(38):36410-36417(2003)Singh, S., et al. J. Biol. Chem. 278(38):36410-36417(2003)Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)

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Cat# BP12337a
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