C109B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NWR8 |
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Other Accession | NP_060388.2 |
Clone Names | 91201038 |
Gene ID | 55013 |
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Other Names | Calcium uniporter regulatory subunit MCUb, mitochondrial, MCUb, Coiled-coil domain-containing protein 109B, CCDC109B, MCUB |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MCUB {ECO:0000303|PubMed:24231807, ECO:0000312|HGNC:HGNC:26076} |
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Function | Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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