TSN Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15631 |
---|---|
Clone Names | 100318033 |
Gene ID | 7247 |
---|---|
Other Names | Translin, 31--, Component 3 of promoter of RISC, C3PO, TSN |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TSN |
---|---|
Function | DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. |
Cellular Location | Cytoplasm. Nucleus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a DNA-binding protein which specificallyrecognizes conserved target sequences at the breakpoint junction ofchromosomal translocations. Translin polypeptides form a multimericstructure that is responsible for its DNA-binding activity.Recombination-associated motifs and translin-binding sites arepresent at recombination hotspots and may serve as indicators ofbreakpoints in genes which are fused by translocations. Thesebinding activities may play a crucial role in chromosomaltranslocation in lymphoid neoplasms.
References
Chiaruttini, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16481-16486(2009)Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Sengupta, K., et al. Biochemistry 45(3):861-870(2006)Kaluzhny, D., et al. J. Biomol. Struct. Dyn. 23(3):257-265(2005)Gupta, G.D., et al. FEBS Lett. 579(14):3141-3146(2005)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.