|Other Names||Indoleamine 2, 3-dioxygenase 2, IDO-2, 11311-, Indoleamine 2, 3-dioxygenase-like protein 1, Indoleamine-pyrrole 2, 3-dioxygenase-like protein 1, IDO2, INDOL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).|
|Tissue Location||Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).|
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Provided below are standard protocols that you may find useful for product applications.
Along with the enzymes encoded by the INDO (MIM 147435)and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 genemetabolizes tryptophan in the kynurenine pathway (Ball et al., 2007[PubMed 17499941]).
Cetindere, T., et al. Cell. Signal. 22(2):197-211(2010)Huttunen, R., et al. Shock 33(2):149-154(2010)Witkiewicz, A.K., et al. J. Am. Coll. Surg. 208(5):781-787(2009)Metz, R., et al. Cancer Res. 67(15):7082-7087(2007)Ball, H.J., et al. Gene 396(1):203-213(2007)
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