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EIF2B1 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q14232
Clone Names 80703063
Additional Information
Gene ID 1967
Other Names Translation initiation factor eIF-2B subunit alpha, eIF-2B GDP-GTP exchange factor subunit alpha, EIF2B1, EIF2BA
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF2B1
Synonyms EIF2BA
Function Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl- initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9USP0}
Research Areas
Citations (0)
citation

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Background

This gene encodes one of five subunits of eukaryotictranslation initiation factor 2B (EIF2B), a GTP exchange factor foreukaryotic initiation factor 2 and an essential regulator forprotein synthesis. Mutations in this gene and the genes encodingother EIF2B subunits have been associated with leukoencephalopathywith vanishing white matter.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hiyama, T.B., et al. J. Mol. Biol. 392(4):937-951(2009)Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)van der Knaap, M.S., et al. Neuropediatrics 38 (5), 264 (2007) :

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$ 277.78
Cat# BP12415c
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