|Other Names||Solute carrier family 22 member 8, Organic anion transporter 3, hOAT3, SLC22A8, OAT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity)|
|Tissue Location||Expressed in kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein involved in thesodium-independent transport and excretion of organic anions, someof which are potentially toxic. The encoded protein is an integralmembrane protein and appears to be localized to the basolateralmembrane of the kidney. Multiple alternatively spliced transcriptvariants that encode different protein isoforms have been describedfor this gene.
Duan, P., et al. Eur. J. Pharmacol. 627 (1-3), 49-55 (2010) :Rodiger, M., et al. Can. J. Physiol. Pharmacol. 88(2):141-146(2010)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Holmes, M.V., et al. PLoS ONE 4 (12), E7960 (2009) :Torres, A.M. World J. Gastroenterol. 14(43):6616-6621(2008)
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