|Other Names||Small nuclear ribonucleoprotein Sm D3, Sm-D3, snRNP core protein D3, SNRPD3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre- catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the smallnuclear ribonucleoprotein core protein family. It is required forpre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.
Gonsalvez, G.B., et al. J. Cell Biol. 178(5):733-740(2007)Ma, Y., et al. Structure 13(6):883-892(2005)Mahler, M., et al. Arthritis Res. Ther. 7 (1), R19-R29 (2005) :Ong, S.E., et al. Nat. Methods 1(2):119-126(2004)Ong, S.E., et al. Nat. Methods 1(2):119-126(2004)
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